Involvement of the sigma1 receptor in the modulation of dopaminergic transmission by amantadine

@article{Peeters2004InvolvementOT,
  title={Involvement of the sigma1 receptor in the modulation of dopaminergic transmission by amantadine},
  author={Magali Peeters and Pascal Romieu and Tangui Maurice and Tsung-Ping Su and Jean-marie Maloteaux and Emmanuel Hermans},
  journal={European Journal of Neuroscience},
  year={2004},
  volume={19}
}
Pharmacological effects of amantadine on dopaminergic transmission are proposed to result from an uncompetitive antagonism at glutamate N‐methyl‐d‐aspartate (NMDA) receptors. However, our previous studies examining amantadine‐mediated dopamine receptor regulation in the rat striatum revealed a discrepancy from a direct interference with glutamate transmission. Preliminary in vitro binding data from the literature suggested the interaction of amantadine with the sigma1 receptor. Therefore, we… 
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