Involvement of the sigma1 receptor in the modulation of dopaminergic transmission by amantadine

@article{Peeters2004InvolvementOT,
  title={Involvement of the sigma1 receptor in the modulation of dopaminergic transmission by amantadine},
  author={M. Peeters and P. Romieu and T. Maurice and T. Su and J. Maloteaux and E. Hermans},
  journal={European Journal of Neuroscience},
  year={2004},
  volume={19}
}
Pharmacological effects of amantadine on dopaminergic transmission are proposed to result from an uncompetitive antagonism at glutamate N‐methyl‐d‐aspartate (NMDA) receptors. However, our previous studies examining amantadine‐mediated dopamine receptor regulation in the rat striatum revealed a discrepancy from a direct interference with glutamate transmission. Preliminary in vitro binding data from the literature suggested the interaction of amantadine with the sigma1 receptor. Therefore, we… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
Hypersensitivity of dopamine transmission in the rat striatum after treatment with the NMDA receptor antagonist amantadine
  • 37
Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum
  • 44
Involvement of sigma receptors in the modulation of the glutamatergic/NMDA neurotransmission in the dopaminergic systems.
  • 53
MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis.
  • 84
Sigma receptors modulate both A9 and A10 dopaminergic neurons in the rat brain: functional interaction with NMDA receptors
  • 85
Locomotor effects of amantadine in the mouse are not those of a typical glutamate antagonist
  • M. Starr, B. Starr
  • Chemistry, Medicine
  • Journal of neural transmission. Parkinson's disease and dementia section
  • 1995
  • 16
Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine.
  • 34
Biphasic effect of sigma receptor ligands on the extracellular concentration of dopamine in the striatum of the rat
  • G. Gudelsky
  • Chemistry, Medicine
  • Journal of Neural Transmission
  • 1999
  • 41
Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant
  • 30
Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons
  • 73
...
1
2
3
4
5
...