Involvement of the sigma1 receptor in the modulation of dopaminergic transmission by amantadine

  title={Involvement of the sigma1 receptor in the modulation of dopaminergic transmission by amantadine},
  author={Magali Peeters and Pascal Romieu and Tangui Maurice and Tsung-Ping Su and Jean-marie Maloteaux and Emmanuel Hermans},
  journal={European Journal of Neuroscience},
Pharmacological effects of amantadine on dopaminergic transmission are proposed to result from an uncompetitive antagonism at glutamate N‐methyl‐d‐aspartate (NMDA) receptors. However, our previous studies examining amantadine‐mediated dopamine receptor regulation in the rat striatum revealed a discrepancy from a direct interference with glutamate transmission. Preliminary in vitro binding data from the literature suggested the interaction of amantadine with the sigma1 receptor. Therefore, we… 
Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands
An overview of the present knowledge of Sigma (σ) receptors is provided, focussing on σ1 ligand neuropharmacology and the role of ρ1 receptors in behavioral animal studies, which have contributed greatly to the potential therapeutic applications of ς1 ligands.
The sigma receptor: evolution of the concept in neuropsychopharmacology.
In vitro and in vitro studies strongly point to the possibility that sigma-1 receptors participate in membrane remodeling and cellular differentiation in the nervous system, and that s Sigma-1 receptor ligands might merely work as modulators of the innate activity of this protein.
Sigma 1 receptor‐mediated increase in hippocampal extracellular dopamine contributes to the mechanism of the anticonvulsant action of neuropeptide Y
The results indicate that NPY‐induced increases in hippocampal dopamine are mediated via sigma’1 receptors and contribute to the anticonvulsant effect of NPY via increased activation of hippocampal D2 receptors.
Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism.
The results suggest that sigma-1 receptor regulates endogenous defence and plasticity mechanisms in experimental parkinsonism andBoosting the activity of this protein may have disease-modifying effects in Parkinson's disease.
Dopamine-1 receptor agonist, but not cocaine, modulates σ1 gene expression in SVG cellsgene expression in SVG cells
The results suggest that the effect of cocaine on σ2 gene expression in the brain might be indirect and mediated through D1R.


Locomotor effects of amantadine in the mouse are not those of a typical glutamate antagonist
  • M. Starr, B. Starr
  • Biology, Chemistry
    Journal of neural transmission. Parkinson's disease and dementia section
  • 1995
The inability of amantadine to potentiate SKF 38393 in this study suggests the mechanism of its anti-akinetic activity differs, from that of conventional glutamate blocking drugs.
Biphasic effect of sigma receptor ligands on the extracellular concentration of dopamine in the striatum of the rat
It is suggestive that dopamine release in the striatum may be modulated by multiple sigma receptor subtypes and that NMDA receptors may mediate the stimulatory effect of sigma ligands on dopamineRelease in the Striatum.
Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons
(+)‐Pentazocine, a potent sigma ligand that lacks affinity for PCP receptors, produced dose‐dependent contralateral circling behavior following microinjection in the substantia nigra of rats, suggesting that sigma receptors are involved in the neural control of movement and the regulation of the ascending dopamine system.