• Corpus ID: 42309571

Involvement of the serotonergic system in the mode of action of the new potential antidepressant agent 5-methoxyindolyl-2-methylamine.

@article{CarranzaGmezCarpintero1993InvolvementOT,
  title={Involvement of the serotonergic system in the mode of action of the new potential antidepressant agent 5-methoxyindolyl-2-methylamine.},
  author={M C Carranza G{\'o}mez-Carpintero and M C Ochoa Estomba},
  journal={Arzneimittel-Forschung},
  year={1993},
  volume={43 8},
  pages={
          809-13
        }
}
5-Methoxyindolyl-2-methylamine (PIM-35) is an indole derivative with effects in animals indicative of antidepressant properties. In the present study an attempt was made to gain some insight into the mechanism of its pharmacological activity. PIM-35 was compared with some antidepressants in tests for serotonin (5HT), noradrenaline (NA) and dopamine (DA) uptake inhibition in vitro. PIM-35 is a weak inhibitor of noradrenaline uptake as compared with the standards used. The IC50 value for dopamine… 
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