Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.

@article{Jochem2004InvolvementOT,
  title={Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.},
  author={Jerzy Jochem},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2004},
  volume={55 1 Pt 1},
  pages={39-55}
}
  • Jerzy Jochem
  • Published 2004 in
    Journal of physiology and pharmacology : an…
The study was undertaken to examine the involvement of the renin-angiotensin system in the reversal by endogenous central histamine of critical haemorrhagic hypotension in anaesthetised Wistar rats. Histamine N-methyltransferase inhibitor metoprine (20 microg) administered intracerebroventricularly at 5 min of critical hypotension 20-25 mmHg produced increases in histamine concentrations as measured 20 min after treatment in the hypothalamus (581.33 +/- 63.23 vs. 488.26 +/- 56.34 ng/g of wet… CONTINUE READING

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