Involvement of the p38 MAP kinase in Cr(VI)-induced growth arrest and apoptosis

@article{Wakeman2005InvolvementOT,
  title={Involvement of the p38 MAP kinase in Cr(VI)-induced growth arrest and apoptosis},
  author={Timothy P. Wakeman and Dorota Wyczechowska and Bo Xu},
  journal={Molecular and Cellular Biochemistry},
  year={2005},
  volume={279},
  pages={69-73}
}
Hexavalent chromium [Cr(VI)] is a carcinogenic genotoxin commonly found in industry and the environment. DNA damage resulting from Cr(VI) exposure triggers numerous stress responses, including activation of cell cycle checkpoints and initiation of apoptosis. Mechanisms controlling these responses, while extensively studied, have yet to be fully elucidated. Here, we demonstrate that the p38 mitogen-activated protein kinase (MAPK) is activated by Cr(VI) exposure and that inhibition of p38… CONTINUE READING
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