Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal.

@article{Georgescu2003InvolvementOT,
  title={Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal.},
  author={Dan Georgescu and Venetia Zachariou and Michel Barrot and Michihiro Mieda and Jon T. Willie and Amelia J Eisch and Masashi Yanagisawa and Eric J Nestler and Ralph Joseph Dileone},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 8},
  pages={3106-11}
}
The lateral hypothalamus (LH) is implicated in the behavioral actions of drugs of abuse, but the cellular and molecular basis of this role is unclear. Recent identification of neuropeptides localized in LH neurons has allowed for more specific studies of LH function. The LH-specific peptide orexin (hypocretin) has been shown to be important in arousal and sleep regulation. However, orexin cells of the LH project broadly throughout the brain such that orexin may influence other behaviors as well… CONTINUE READING
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