Involvement of the insulin-like growth factor binding proteins in the cancer cell response to DNA damage

Abstract

The complex mechanisms that cells have evolved to meet the challenge of constant exposure to DNA-damaging stimuli, also serve to protect cancer cells from the cytotoxic effects of chemo- and radiotherapy. IGFBPs appear to be involved, directly or indirectly, in some of these protective mechanisms. Activation of p53 is an early response to genotoxic stress… (More)
DOI: 10.1007/s12079-015-0262-1

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