Involvement of the inhibition of intestinal glucuronidation in enhancing the oral bioavailability of resveratrol by labrasol containing nanoemulsions.

@article{Zhou2015InvolvementOT,
  title={Involvement of the inhibition of intestinal glucuronidation in enhancing the oral bioavailability of resveratrol by labrasol containing nanoemulsions.},
  author={Jing Zhou and Man Zhou and Fei-fei Yang and Chun-Yu Liu and Ruile Pan and Qi Chang and Xinmin Liu and Yong-hong Liao},
  journal={Molecular pharmaceutics},
  year={2015},
  volume={12 4},
  pages={1084-95}
}
Nanoemulsions have been developed for the oral delivery of poorly bioavailable phenolic compounds that are sensitive to intestinal glucuronidation. However, little is known about the contribution of UDP-glucuronosyltransferase (UGT) inhibitory excipients in nanoemulsions toward the inhibition of intestinal glucuronidation and the consequent enhanced bioavailability. In this study, Labrasol but not poloxamer 188 (F68) was found to inhibit the glucuronidation of resveratrol (RES), a model… CONTINUE READING

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