Involvement of the hypothalamic-pituitary-adrenal axis in the antidepressant-like effects of mild hypoxic preconditioning in rats.

@article{Rybnikova2007InvolvementOT,
  title={Involvement of the hypothalamic-pituitary-adrenal axis in the antidepressant-like effects of mild hypoxic preconditioning in rats.},
  author={Elena Rybnikova and V. G. Mironova and Svetlana Pivina and Ekaterina Tulkova and Natalia Ordyan and Natalia N. Nalivaeva and Anthony J. Turner and Michail Olegovich Samoilov},
  journal={Psychoneuroendocrinology},
  year={2007},
  volume={32 7},
  pages={813-23}
}
The preconditioning (PC) by using mild intermittent hypobaric hypoxia (PC) increases a resistance of the brain to severe hypoxia/ischemia and various stresses. Recently, potent antidepressant-like effects of PC have been described in animal models of depression. In the present study, the impact of PC on the activity and feedback regulation of the hypothalamic-pituitary-adrenal axis (HPA) impaired in depression has been studied in the model of shock-induced depression in rats. PC completely… CONTINUE READING

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