Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription.

@article{Watada1996InvolvementOT,
  title={Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription.},
  author={Hirotaka Watada and Yoshitaka Kajimoto and Hideaki Kaneto and Taka-aki Matsuoka and Yoshio Fujitani and Jun ichi Miyazaki and Yoshimitsu Yamasaki},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={229 3},
  pages={746-51}
}
The AT-rich cis-motif A elements of the insulin gene promoter contribute to directing the gene's expression to pancreatic beta-cells, bound by a homeodomain-containing transcription factor, PDX-1/IPF1/STF-1/IDX-1. The islet amyloid polypeptide (IAPP; amylin) gene, which is also expressed in limited tissues such as pancreatic beta- and delta-cells, contained similar AT-rich sequences in its regulatory sequences. To understand the molecular basis of IAPP gene regulation, we evaluated the possible… CONTINUE READING

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