Involvement of the glutamate receptor delta 2 subunit in the long-term depression of glutamate responsiveness in cultured rat Purkinje cells.

@article{Hirano1994InvolvementOT,
  title={Involvement of the glutamate receptor delta 2 subunit in the long-term depression of glutamate responsiveness in cultured rat Purkinje cells.},
  author={Tsutomu Hirano and Keizo Kasono and Kazuaki Araki and Kazumasa Shinozuka and Masayoshi Mishina},
  journal={Neuroscience letters},
  year={1994},
  volume={182 2},
  pages={172-6}
}
An antisense oligonucleotide against the glutamate receptor delta 2 subunit mRNA, which is selectively expressed only in Purkinje neurons, suppressed the induction of long-term depression (LTD) of glutamate responsiveness in the rat cerebellar culture. LTD of glutamate response is induced by pairing glutamate application and depolarization of a Purkinje cell. Treatment of the culture with the antisense oligonucleotide exerted no appreciable effect on basic physiological and morphological… CONTINUE READING
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