Involvement of the fourth alpha-helix of mouse granulocyte-macrophage colony-stimulating factor in binding to the alpha-subunit of the receptor complex.

Abstract

Mouse granulocyte-macrophage colony-stimulating factor (mGM-CSF) proteins with substitutions for residues located within alpha-helix D were examined for biological activity and receptor binding properties. Alanine substitutions of the surface exposed positions indicated that several residues contribute to the ligand-receptor interface. Position K108 and… (More)

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@article{Altmann1995InvolvementOT, title={Involvement of the fourth alpha-helix of mouse granulocyte-macrophage colony-stimulating factor in binding to the alpha-subunit of the receptor complex.}, author={Scott W Altmann and N Patel and Ronald A. Kastelein}, journal={Growth factors}, year={1995}, volume={12 4}, pages={251-62} }