Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.

@article{Valjent2000InvolvementOT,
  title={Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.},
  author={Emmanuel Valjent and Jean Christophe Corvol and Christiane Pag{\`e}s and M. J. Besson and Rafael Maldonado and Jocelyne Caboche},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 23},
  pages={8701-9}
}
A central feature of drugs of abuse is to induce gene expression in discrete brain structures that are critically involved in behavioral responses related to addictive processes. Although extracellular signal-regulated kinase (ERK) has been implicated in several neurobiological processes, including neuronal plasticity, its role in drug addiction remains poorly understood. This study was designed to analyze the activation of ERK by cocaine, its involvement in cocaine-induced early and long-term… CONTINUE READING
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