Involvement of the dorsomedial striatum in behavioral flexibility: role of muscarinic cholinergic receptors.

@article{Ragozzino2002InvolvementOT,
  title={Involvement of the dorsomedial striatum in behavioral flexibility: role of muscarinic cholinergic receptors.},
  author={Michael E. Ragozzino and Jane Jih and Arianna Tzavos},
  journal={Brain research},
  year={2002},
  volume={953 1-2},
  pages={205-14}
}
The present experiments determined whether temporary inactivation or blockade of muscarinic cholinergic receptors in the dorsomedial striatum affects acquisition or reversal learning of a response discrimination. Testing occurred in a modified cross-maze across two consecutive sessions. In the acquisition phase, a rat learned to make a turn to the left or to the right for 10 consecutive correct choices. In the reversal learning phase, a rat learned to turn in the opposite direction as required… CONTINUE READING

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