Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH.

@article{Nakatani2011InvolvementOT,
  title={Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH.},
  author={Yoshihito Nakatani and Yutaka Hokonohara and Yusuke Tajima and Ichiro Kudo and Shuntaro Hara},
  journal={Prostaglandins & other lipid mediators},
  year={2011},
  volume={94 3-4},
  pages={112-7}
}
We previously showed that cytosolic prostaglandin (PG) E synthase (cPGES/p23) which isomerizes PGH(2) to PGE(2), is essential for fetal mouse development. Embryonic fibroblasts derived from cPGES/p23 knockout mice generated higher amounts of PGE(2) in culture supernatants than wild-type-derived cells. In order to elucidate this apparent conflict that absence of PGE(2) synthetic enzyme caused facilitation of PGE(2) biosynthesis, we examined expression of the PGE(2) degrading enzyme in embryonic… CONTINUE READING

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