Involvement of the carboxyl-terminal region in modulation by TPA of the NMDA receptor channel.

@article{Mori1993InvolvementOT,
  title={Involvement of the carboxyl-terminal region in modulation by TPA of the NMDA receptor channel.},
  author={Hisashi Mori and Tomohiro Yamakura and Hisashi Masaki and Masayoshi Mishina},
  journal={Neuroreport},
  year={1993},
  volume={4 5},
  pages={519-22}
}
The epsilon 1/zeta 1 and epsilon 2/zeta 1 heteromeric N-methyl-D-aspartate (NMDA) receptor channels expressed in Xenopus oocytes, but not the epsilon 3/zeta 1 and epsilon 4/zeta 1 channels, are positively modulated by the treatment with 12-O-tetradecanoyl phorbol 13-acetate (TPA). Failure of potentiation in the presence of staurosporine suggests the involvement of protein kinases in the TPA effect. To identify the structural domain involved in the modulation of the NMDA receptor channel by the… CONTINUE READING