Involvement of the brain type of ryanodine receptor in T-cell proliferation.

  title={Involvement of the brain type of ryanodine receptor in T-cell proliferation.},
  author={Youji Hakamata and Seiichiro Nishimura and Junichi Nakai and Yukiko Nakashima and Toshiyuki Kita and Keiji Imoto},
  journal={FEBS letters},
  volume={352 2},
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506. 

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