Involvement of the XRCC1 Arg399Gln gene polymorphism in the development of cervical carcinoma.

@article{Roszak2011InvolvementOT,
  title={Involvement of the XRCC1 Arg399Gln gene polymorphism in the development of cervical carcinoma.},
  author={Andrzej Roszak and Margarita Lianeri and Pawel P Jagodziński},
  journal={The International journal of biological markers},
  year={2011},
  volume={26 4},
  pages={216-20}
}
BACKGROUND Although infection with the human papillomavirus (HPV) is crucial to the development of cervical cancer, it is not considered a sufficient isolated factor to cause this malignancy. The association of the XRCC1 Arg399Gln (rs25487) polymorphism with cervical cancer has been demonstrated in some populations. METHODS The XRCC1 Arg399Gln genetic variants were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in patients with advanced cervical… CONTINUE READING
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