Involvement of the Sigma1 Receptor in Cocaine-induced Conditioned Place Preference: Possible Dependence on Dopamine Uptake Blockade

@article{Romieu2002InvolvementOT,
  title={Involvement of the Sigma1 Receptor in Cocaine-induced Conditioned Place Preference: Possible Dependence on Dopamine Uptake Blockade},
  author={Pascal Romieu and V L Phan and R{\'e}mi Martin-Fardon and Tangui Maurice},
  journal={Neuropsychopharmacology},
  year={2002},
  volume={26},
  pages={444-455}
}
The involvement of the sigma1 receptor on the rewarding effects of cocaine was examined using the conditioned place preference (CPP) procedure in C57BL/6 mice. Acquisition or expression of cocaine (20 mg/kg i.p.)-induced CPP was significantly decreased by pre-treatment with the selective sigma1 receptor antagonists N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine (NE-100) or N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine (BD1047), 1–10 mg/kg, i.p. The sigma1… CONTINUE READING
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