Involvement of the PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora.

  title={Involvement of the PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora.},
  author={Shefalee K. Bhavsar and Michael F{\"o}ller and Shuchen Gu and Sanjay Vir and Mamta B Shah and Kamlesh Kumar Bhutani and Dev Das Santani and Florian Lang},
  journal={Journal of ethnopharmacology},
  volume={126 3},
AIM OF THE STUDY Saponins from Helicteres isora have previously been shown to exert antidiabetic effects. The present study explored the underlying mechanisms in C2C12 skeletal muscle cells. MATERIALS AND METHODS C2C12 cells were incubated with saponins and sapogenin followed by Western blotting and immunofluorescence analysis. RESULTS Western blotting revealed that incubation with saponins (100 microg/ml) and sapogenin (100 microg/ml) induced the phosphorylation of the phosphatidylinositol… CONTINUE READING


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