Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.

  title={Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.},
  author={Etsu Tashiro and Shizuka Henmi and Hiroyuki Odake and Seitaro Ino and Masaya Imoto},
  journal={Biochemical and biophysical research communications},
  volume={477 4},
E-cadherin is a major component of the epithelial adherens junction. However, the regulatory mechanism of E-cadherin expression is still poorly understood. In this study, we found that EGF decreased E-cadherin expression at both mRNA and protein levels in colorectal carcinoma LoVo cells. Since E-cadherin down-regulation is a well-known hallmark of the EMT (Epithelial-Mesenchymal Transition), we investigated whether EGF induced E-cadherin down-regulation during the EMT. EGF was unable to affect… CONTINUE READING

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