Involvement of the M7/M8 extracellular loop of the sodium pump alpha subunit in ion transport. Structural and functional homology to P-loops of ion channels.

@article{Schneider1997InvolvementOT,
  title={Involvement of the M7/M8 extracellular loop of the sodium pump alpha subunit in ion transport. Structural and functional homology to P-loops of ion channels.},
  author={Heike Schneider and Georgios Scheiner-Bobis},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 26},
  pages={16158-65}
}
Mutations were introduced in the motif 884DDRW887 from an extracellular peptide of the sodium pump alpha subunit localized between M7 and M8 membrane spans to investigate a possible role of this structure in ion recognition. A homologous sequence 399QDCW402 that occurs in the P-loops of Na+ channels was shown earlier to be important for ion gating. Mutant sodium pumps were expressed in yeast and subsequently investigated for their behavior toward ouabain, Na+, K+, and ATP. Native enzyme and… CONTINUE READING

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