Involvement of the Lamin Rod Domain in Heterotypic Lamin Interactions Important for Nuclear Organization

@article{Schirmer2001InvolvementOT,
  title={Involvement of the Lamin Rod Domain in Heterotypic Lamin Interactions Important for Nuclear Organization},
  author={Eric C. Schirmer and Tinglu Guan and Larry Gerace},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={153},
  pages={479 - 490}
}
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea. To investigate lamina functions, we have characterized a novel lamin B1 mutant lacking the middle approximately 4/5 of its alpha-helical rod domain. Though retaining only 10 heptads of the rod, this mutant assembles into intermediate filament-like… CONTINUE READING
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