Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue

@inproceedings{Matsumura1988InvolvementOT,
  title={Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue},
  author={Yasuhiro Matsumura and Masami Kimura and Tetsuro Yamamoto and Hiroshi Maeda},
  booktitle={Japanese journal of cancer research : Gann},
  year={1988}
}
Enhanced vascular permeability in tumor tissue has profound pathological consequences in tumor biology. However, details of the mechanism involved are not clear. The present work on tumor vascular permeability has led to the following three findings. (i) Ascitic tumor fluid contained kinin (about 1-40 ng/ml), which is known to enhance vascular permeability and induce pain in vivo. (ii) Kinin is generated via the kallikrein-dependent cascade in the ascitic tumor fluid. By blocking this kinin… CONTINUE READING
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