Involvement of the IGF system in fetal growth and childhood cancer: an overview of potential mechanisms

@article{Callan2009InvolvementOT,
  title={Involvement of the IGF system in fetal growth and childhood cancer: an overview of potential mechanisms},
  author={Anna C Callan and Elizabeth Milne},
  journal={Cancer Causes & Control},
  year={2009},
  volume={20},
  pages={1783-1798}
}
Fetal growth is determined by a complex interplay of genetic, nutritional, environmental, and hormonal factors. Greater than expected fetal growth has been positively associated with the risk of the development of some cancers in childhood, particularly acute lymphoblastic leukemia, and the biological mechanisms underlying such associations are thought to involve insulin-like growth factors (IGFs). Circulating IGF levels are highly correlated with fetal growth, and IGFs are believed to play an… CONTINUE READING

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