Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex.

@article{Shimokawa2003InvolvementOT,
  title={Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex.},
  author={Takashi Shimokawa and Yoichi Furukawa and Michihiro Sakai and Meihua Li and Nobutomo Miwa and Yu-Min Lin and Yusuke Nakamura},
  journal={Cancer research},
  year={2003},
  volume={63 19},
  pages={
          6116-20
        }
}
To search for potential molecular targets for development of novel anticancer drugs, we have been analyzing expression profiles of clinical samples from cancer patients, using a genome-wide cDNA microarray. In experiments with colon cancer cells, the gene encoding fibroblast growth factor 18 (FGF18) was among those that showed elevated expression. The promoter region of this gene was found to contain putative Tcf4-binding motifs; moreover a reporter-gene assay using luciferase activity as a… CONTINUE READING

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