Involvement of the Endocannabinoid System in the Ability of Long-Term Tricyclic Antidepressant Treatment to Suppress Stress-Induced Activation of the Hypothalamic–Pituitary–Adrenal Axis

@article{Hill2006InvolvementOT,
  title={Involvement of the Endocannabinoid System in the Ability of Long-Term Tricyclic Antidepressant Treatment to Suppress Stress-Induced Activation of the Hypothalamic–Pituitary–Adrenal Axis},
  author={Matthew Nicholas Hill and W S V Ho and Katia Joanne Sinopoli and Victor Viau and Cecilia J. Hillard and Boris B. Gorzalka},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={2591-2599}
}
The efficacy of antidepressants has been linked in part to their ability to reduce activity of the hypothalamic–pituitary–adrenal (HPA) axis; however, the mechanism by which antidepressants regulate the HPA axis is largely unknown. Given that recent research has demonstrated that endocannabinoids can regulate the HPA axis and exhibit antidepressant potential, we examined the hypothesis that the endocannabinoid system is regulated by long-term antidepressant treatment. Three-week administration… CONTINUE READING

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