Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects: an isobologram analysis.

@article{Naseri2014InvolvementOT,
  title={Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects: an isobologram analysis.},
  author={Mohammad-Hasan Naseri and Saeed Hesami-Tackallou and Mohammad Torabi-Nami and Mohammad Reza Zarrindast and Mohammad Mahdi Nasehi},
  journal={Behavioural pharmacology},
  year={2014},
  volume={25 3},
  pages={197-205}
}
There seems to be a close relationship between hippocampal N-methyl-D-aspartic acid (NMDA) and GABAA receptors with respect to the modulation of behavior that occurs in the CA1 region of the hippocampus. This study investigated the possible involvement of the CA1 GABAA receptors in anxiolytic-like effects induced by (+)-MK-801 (a noncompetitive antagonist of the NMDA subtype of the glutamate receptor). Male Wistar rats were subjected to the elevated plus-maze apparatus and open arm time (%OAT… CONTINUE READING