Involvement of the Arg179 in the active site of human IL-6.

@article{Fontaine1993InvolvementOT,
  title={Involvement of the Arg179 in the active site of human IL-6.},
  author={Valerie Fontaine and Rocco Savino and Rosaria Arcone and Laurence Th de Wit and Jan P. G. Brakenhoff and J. Content and G. Ciliberto},
  journal={European journal of biochemistry},
  year={1993},
  volume={211 3},
  pages={749-55}
}
Three internal-amino acid deletions of amino acids 171-179 of human interleukin 6 (IL-6) were introduced at the cDNA level. While all deletion proteins were biologically inactive, immunoprecipitations with a set of conformation-specific anti-(IL-6) monoclonal antibodies showed that only mutant delta 177-179 does not present major alterations in folding. This finding, together with the observation that delta 177-179 is not able to compete with IL-6 for binding to the soluble human IL-6 receptor… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…