Involvement of tachykinins in pentamidine-induced airway constriction and microvascular leakage in the guinea pig.

@article{Jarreau1993InvolvementOT,
  title={Involvement of tachykinins in pentamidine-induced airway constriction and microvascular leakage in the guinea pig.},
  author={Pierre Henri Jarreau and A. Harf and Micheline Levame and V Boyer and Hubert Lorino and Isabelle Macquin‐Mavier},
  journal={The American review of respiratory disease},
  year={1993},
  volume={147 6 Pt 1},
  pages={
          1544-9
        }
}
We investigated the effects of aerosolized pentamidine isethionate on airway constriction and microvascular leakage in the guinea pig, and the role of tachykinins in these abnormalities. The bronchoconstrictor response to pentamidine was determined in anesthetized, tracheotomized and mechanically ventilated guinea pigs by exposing them to increasing concentrations of aerosolized pentamidine (5 to 30 mg/ml; 60 breaths). Respiratory system resistance was measured by the occlusion method. Airway… 

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