Involvement of tachykinin receptors in Clostridium perfringens beta-toxin-induced plasma extravasation.

@article{Nagahama2003InvolvementOT,
  title={Involvement of tachykinin receptors in Clostridium perfringens beta-toxin-induced plasma extravasation.},
  author={Masahiro Nagahama and Shinsuke Morimitsu and Atsushi Kihara and Masahiko Akita and Koujun Setsu and J. J. Sakurai},
  journal={British journal of pharmacology},
  year={2003},
  volume={138 1},
  pages={23-30}
}
1 Clostridium perfringens beta-toxin causes dermonecrosis and oedema in the dorsal skin of animals. In the present study, we investigated the mechanisms of oedema induced by the toxin. 2 The toxin induced plasma extravasation in the dorsal skin of Balb/c mice. 3 The extravasation was significantly inhibited by diphenhydramine, a histamine 1 receptor antagonist. However, the toxin did not cause the release of histamine from mouse mastocytoma cells. 4 Tachykinin NK(1) receptor antagonists, [D-Pro… CONTINUE READING

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