Involvement of survival motor neuron (SMN) protein in cell death.

@article{Vyas2002InvolvementOS,
  title={Involvement of survival motor neuron (SMN) protein in cell death.},
  author={Sheela Vyas and Catherine B{\'e}chade and B{\'e}atrice Riveau and Julian Downward and Antoine Triller},
  journal={Human molecular genetics},
  year={2002},
  volume={11 22},
  pages={
          2751-64
        }
}
Infantile spinal muscular atrophy (SMA) is caused by mutations in the survival motor neuron (SMN)1 gene. We investigated the role of human (h) SMN protein on cell death in PC12 and Rat-1 cells. hSMN prolonged cell survival in PC12 cells deprived of trophic support and in Rat-1 cells induced to die by activation of the proto-oncogene c-Myc, to similar magnitude as Bcl-2 or IAP-2. While hSMN was ineffective in inhibiting apoptosis induced by ultraviolet light (UV) or etoposide treatment in… CONTINUE READING

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