Involvement of substance P and the NK-1 receptor in cancer progression

@article{Muoz2013InvolvementOS,
  title={Involvement of substance P and the NK-1 receptor in cancer progression},
  author={M. Mu{\~n}oz and R. Cove{\~n}as},
  journal={Peptides},
  year={2013},
  volume={48},
  pages={1-9}
}
Many data suggest the deep involvement of the substance P (SP)/neurokinin (NK)-1 receptor system in cancer: (1) Tumor cells express SP, NK-1 receptors and mRNA for the tachykinin NK-1 receptor; (2) Several isoforms of the NK-1 receptor are expressed in tumor cells; (3) the NK-1 receptor is involved in the viability of tumor cells; (4) NK-1 receptors are overexpressed in tumor cells in comparison with normal ones and malignant tissues express more NK-1 receptors than benign tissues; (5) Tumor… Expand
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