Involvement of subchondral bone marrow in rheumatoid arthritis: lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment.

@article{Bugatti2005InvolvementOS,
  title={Involvement of subchondral bone marrow in rheumatoid arthritis: lymphoid neogenesis and in situ relationship to subchondral bone marrow osteoclast recruitment.},
  author={Serena Bugatti and Roberto Caporali and Antonio Manzo and Barbara Vitolo and Costantino Pitzalis and Carlomaurizio Montecucco},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 11},
  pages={3448-59}
}
OBJECTIVE To evaluate the presence and immunohistochemical characteristics of subchondral bone marrow inflammatory infiltrate in rheumatoid arthritis (RA) and to determine the in situ relationship between marrow inflammation and osteoclast recruitment. METHODS Bone samples and paired synovia from 8 RA patients undergoing joint surgery were analyzed by immunohistochemistry and in situ hybridization for specific lymphoid neogenetic features, such as T and B cell composition, follicular… CONTINUE READING

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