Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in rats.

Abstract

Phosphorylation of a subunit of N-methyl-D-aspartate (NMDA) receptor by protein tyrosine kinase (PTK) Src or Trk is known to enhance its channel activity. We examined whether a spinally administered selective PTK inhibitor, lavendustin A, which has high affinity for Src and Trk tyrosine kinases, could influence the development and maintenance of… (More)

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Cite this paper

@article{Sato2003InvolvementOS, title={Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in rats.}, author={Eiru Sato and Yoshito Takano and Yuichiro Kuno and Manami Takano and Isao Sato}, journal={European journal of pharmacology}, year={2003}, volume={468 3}, pages={191-8} }