Involvement of spinal sensory pathway in ALS and specificity of cord atrophy to lower motor neuron degeneration.

  title={Involvement of spinal sensory pathway in ALS and specificity of cord atrophy to lower motor neuron degeneration.},
  author={Julien Cohen-Adad and M M El Mendili and R{\'e}gine Morizot-Koutlidis and St{\'e}phane Leh{\'e}ricy and Vincent Meininger and S. Blancho and Serge Rossignol and Habib Benali and P-F Pradat},
  journal={Amyotrophic lateral sclerosis & frontotemporal degeneration},
  volume={14 1},
Our objective was to demonstrate that ALS patients have sensory pathway involvement and that local cord atrophy reflects segmental lower motor neuron involvement. Twenty-nine ALS patients with spinal onset and twenty-one healthy controls were recruited. Diffusion tensor imaging (DTI), magnetization transfer and atrophy index were measured in the spinal cord, complemented with transcranial magnetic stimulations. Metrics were quantified within the lateral corticospinal and the dorsal segments of… CONTINUE READING
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