Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages.

@article{Vanderheijden2003InvolvementOS,
  title={Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages.},
  author={Nathalie Vanderheijden and Peter Delputte and Herman W. Favoreel and Jo{\"e}l Vandekerckhove and Jozef Van Damme and Peter A van Woensel and Hans Nauwynck},
  journal={Journal of virology},
  year={2003},
  volume={77 15},
  pages={8207-15}
}
Porcine reproductive and respiratory syndrome virus (PRRSV) shows a very restricted tropism for cells of the monocyte/macrophage lineage. It enters cells via receptor-mediated endocytosis. A monoclonal antibody (MAb) that is able to block PRRSV infection of porcine alveolar macrophages (PAM) and that recognizes a 210-kDa protein (p210) was described previously (MAb41D3) (X. Duan, H. Nauwynck, H. Favoreel, and M. Pensaert, J. Virol. 72:4520-4523, 1998). In the present study, the p210 protein was… CONTINUE READING
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