Involvement of selenoprotein P and GPx4 gene expression in cadmium-induced testicular pathophysiology in rat.

@article{Messaoudi2010InvolvementOS,
  title={Involvement of selenoprotein P and GPx4 gene expression in cadmium-induced testicular pathophysiology in rat.},
  author={Imed Messaoudi and Mohamed Banni and Lamia Sa{\"i}d and Khaled Sa{\"i}d and Abdelhamid Kerkeni},
  journal={Chemico-biological interactions},
  year={2010},
  volume={188 1},
  pages={94-101}
}
To investigate the effect of co-exposure to cadmium (Cd) and selenium (Se) on selenoprotein P (SelP) and phospholipid hydroperoxide glutathione peroxidase (GPx4) gene expression in testis and to evaluate their possible involvement in Cd-induced testicular pathophysiology, male rats received either tap water, Cd or Cd+Se in their drinking water for 5 weeks. Cd exposure caused a down-regulation of SelP and GPx4 gene expression and a significant decrease in plasma and testicular concentrations of… CONTINUE READING
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