Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage.


Neuronal death evoked by DNA damage requires cyclin-dependent kinase 4 (Cdk4) and 6 activity and is accompanied by elevation of cyclin D1-associated kinase activity. Because Cdk4/6 phosphorylates retinoblastoma protein (pRb) family members that then modulate the transcriptional activity of E2F/DP1 complexes, we examined the involvement of these components… (More)

10 Figures and Tables


  • Presentations referencing similar topics