Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats.

@article{Kobuchi2014InvolvementOR,
  title={Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats.},
  author={Shuhei Kobuchi and Ryosuke Tanaka and Asami Funai and Rie Suzuki and Maki Yazawa and Hidenobu Tsutsui and Mamoru Ohkita and Kazuhide Ayajiki and Yasuo Matsumura},
  journal={Journal of cardiovascular pharmacology},
  year={2014},
  volume={63 1},
  pages={9-15}
}
Time-dependent changes in the renal sympathetic nerve activity (RSNA) in the progression of chronic kidney disease (CKD) have not been investigated, despite the fact that renal sympathetic nervous system is augmented in the condition of CKD. In the present study, we examined time-dependent changes in RSNA and renal venous norepinephrine concentrations for 12 weeks using 5 of 6 nephrectomized CKD rats. Both RSNA and norepinephrine concentrations were increased during the early phase in the… CONTINUE READING
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