Involvement of regulatory T cells in the immunosuppression characteristic of patients with paracoccidioidomycosis.

@article{Ferreira2010InvolvementOR,
  title={Involvement of regulatory T cells in the immunosuppression characteristic of patients with paracoccidioidomycosis.},
  author={Maria Carolina Salmora Ferreira and R{\^o}mulo Tadeu Dias de Oliveira and Rosiane Maria da Silva and Maria Heloisa Souza Lima Blotta and Ronei Luciano Mamoni},
  journal={Infection and immunity},
  year={2010},
  volume={78 10},
  pages={
          4392-401
        }
}
Patients with paracoccidioidomycosis (PCM) exhibit a suppression of the cellular immune response characterized by negative delayed-type hypersensitivity (DTH) to Paracoccidioides brasiliensis antigens, the apoptosis of lymphocytes, and high levels of expression of cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4), interleukin-10 (IL-10), and transforming growth factor β (TGF-β). The aim of this study was to investigate whether and how regulatory T cells (Treg cells) are involved in this… CONTINUE READING

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Characterization of the immune response in human paracoccidioidomycosis.

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