Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells.

@article{Baulig2003InvolvementOR,
  title={Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells.},
  author={Augustin Baulig and Mich{\`e}le Garlatti and V{\'e}ronique Bonvallot and Alexandre Marchand and Robert Barouki and Francelyne Marano and Armelle Baeza-Squiban},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 3},
  pages={L671-9}
}
Diesel exhaust particles (DEP) induce a proinflammatory response in human bronchial epithelial cells (16HBE) characterized by the release of proinflammatory cytokines after activation of transduction pathways involving MAPK and the transcription factor NF-kappaB. Because cellular effects induced by DEP are prevented by antioxidants, they could be mediated by reactive oxygen species (ROS). Using fluorescent probes, we detected ROS production in bronchial and nasal epithelial cells exposed to… CONTINUE READING
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