Involvement of reactive oxygen species in aflatoxin B1-induced cell injury in cultured rat hepatocytes.

@article{Shen1995InvolvementOR,
  title={Involvement of reactive oxygen species in aflatoxin B1-induced cell injury in cultured rat hepatocytes.},
  author={H M Shen and Choon Nam Ong and Christina Y Shi},
  journal={Toxicology},
  year={1995},
  volume={99 1-2},
  pages={115-23}
}
The role of reactive oxygen species (ROS) in AFB1-induced cell injury was investigated using cultured rat hepatocytes. Malonaldehyde (MDA) generation and lactate dehydrogenase (LDH) release were determined as indices of lipid peroxidation and cell injury, respectively. Exposure to AFB1 for up to 72 h resulted in significantly elevated levels of LDH being released into the medium as well as the MDA generation in cultured hepatocytes. These effects were dose-dependent, indicating that AFB1 was… CONTINUE READING

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