Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B.

@article{Asehnoune2004InvolvementOR,
  title={Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B.},
  author={Karim Asehnoune and Derek Strassheim and Sanchayita Mitra and Jae Yeol Kim and Edward Abraham},
  journal={Journal of immunology},
  year={2004},
  volume={172 4},
  pages={2522-9}
}
Although oxidative stress has been thought to play a general role in the activation of NF-kappaB, the involvement of reactive oxygen species (ROS) in facilitating nuclear translocation of NF-kappaB in neutrophils has not been described. In addition, the mechanisms by which ROS modulate the transcriptional activity of NF-kappaB in response to Toll-like receptor 4 (TLR4)-dependent signaling are not well characterized. To examine these issues, oxidant-dependent signaling events downstream of TLR4… CONTINUE READING
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