Involvement of reactive oxygen species in TNF-alpha mediated activation of the transcription factor NF-kappaB in canine dermal fibroblasts.

@article{Khler1999InvolvementOR,
  title={Involvement of reactive oxygen species in TNF-alpha mediated activation of the transcription factor NF-kappaB in canine dermal fibroblasts.},
  author={H B K{\"o}hler and Johannes Knop and Margarita Mart{\'i}n and Alain de Bruin and Bernhard Huchzermeyer and Heidi Lehmann and Manfred Kietzmann and B. Stefanie Meier and Ingo Nolte},
  journal={Veterinary immunology and immunopathology},
  year={1999},
  volume={71 2},
  pages={125-42}
}
The cytokine tumor necrosis factor-alpha (TNF-alpha) plays a major role in inflammatory and immune-pathological reactions of the skin. With respect to a possible therapeutic modulation of TNF-alpha mediated activation of Nuclear Factor-kappa B (NF-kappaB) in canine cutaneous inflammation, we investigated the role of NF-kappaB and the involvement of reactive oxygen species (ROS) in the TNF-alpha signalling pathway in dermal fibroblasts of the dog. TNF-alpha treatment resulted in the activation… CONTINUE READING