Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL.

@article{Akiba2003InvolvementOR,
  title={Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL.},
  author={Satoshi Akiba and Masahiro Chiba and Yuki Mukaida and Takashi Sato},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={310 2},
  pages={491-7}
}
We examined the mechanisms responsible for the production of fibronectin induced by oxidized low-density lipoprotein (oxLDL) in rat mesangial cells. oxLDL accelerated the production of fibronectin with the preceding generation of reactive oxygen species (ROS). Pretreatment with N-acetylcysteine suppressed the oxLDL-induced fibronectin production as well as ROS generation. oxLDL also elicited the activation of SP-1, nuclear factor-kappaB, and cAMP response element-binding protein, but not… CONTINUE READING