Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons

@article{Borasio1993InvolvementOR,
  title={Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons},
  author={Gian Domenico Borasio and Annette Markus and Alfred Wittinghofer and Y. - A. Barde and Rolf Heumann},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={121},
  pages={665 - 672}
}
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family. We have previously shown that the introduction of the oncogene product ras p21 into the cytoplasm of chick embryonic neurons can reproduce the survival and neurite-outgrowth promoting effects of the neurotrophins nerve growth factor (NGF) and… CONTINUE READING

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Inhibition of the Borasio et al

  • M. Ohmichi, S. J. Decker, L. Pang, A. R. Saltiel.
  • ras Involvement in Neurotrophic Response
  • 1992
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