Corpus ID: 25511842

Involvement of protein kinase in the regulation of beta-adrenergic receptors by antidepressants.

@article{Asakura1989InvolvementOP,
  title={Involvement of protein kinase in the regulation of beta-adrenergic receptors by antidepressants.},
  author={Mikio Asakura and Tohru Tsukamoto and H. Kubota and Kenichi Osada and Jun Imafuku and Jun Nishizaki and Atsuko Sato and J Nakanishi and Kazutaka Shimbo and Makiko Shibata},
  journal={International journal of clinical pharmacology research},
  year={1989},
  volume={9 2},
  pages={
          123-30
        }
}
The role of serotonin (5-HT) and protein kinases in the regulation of the beta-receptor induced by typical and atypical antidepressants was investigated. Treatment with either mianserin or maprotiline for seven days produced a significant decrease in the beta-receptor density measured 6h after the last dose. The reduction in beta-receptors disappeared within 24h. However, combined treatment of mianserin or maprotiline with either fluoxetine or 5-hydroxytryptophan significantly decreased beta… Expand
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