Corpus ID: 25511842

Involvement of protein kinase in the regulation of beta-adrenergic receptors by antidepressants.

  title={Involvement of protein kinase in the regulation of beta-adrenergic receptors by antidepressants.},
  author={Mikio Asakura and Tohru Tsukamoto and H. Kubota and Kenichi Osada and Jun Imafuku and Jun Nishizaki and Atsuko Sato and J Nakanishi and Kazutaka Shimbo and Makiko Shibata},
  journal={International journal of clinical pharmacology research},
  volume={9 2},
The role of serotonin (5-HT) and protein kinases in the regulation of the beta-receptor induced by typical and atypical antidepressants was investigated. Treatment with either mianserin or maprotiline for seven days produced a significant decrease in the beta-receptor density measured 6h after the last dose. The reduction in beta-receptors disappeared within 24h. However, combined treatment of mianserin or maprotiline with either fluoxetine or 5-hydroxytryptophan significantly decreased beta… Expand
4 Citations
Idazoxan down-regulates β-adrenoceptors on C6 glioma cells in vitro
Results suggest that idazoxan may have direct postsynaptic effects, the site of which may be at the level of receptor/G protein interaction. Expand
The combined effects of chronic ethanol/desipramine treatment on beta-adrenoceptor density and coupling efficiency in rat brain.
Ethanol enhanced desipramine-induced decrease in beta-adrenoceptor density in the high-conformational state, but uncoupled beta- adrenoceptors, an effect not observed with ethanol alone. Expand
Neutrophil beta(2)-adrenoceptor function in major depression: G(s) coupling, effects of imipramine and relationship to treatment outcome.
Differences in beta(2)-adrenoceptor regulation in major depressive disorder may underlie treatment response, and the results indirectly implicate abnormal agonist-mediated beta( 2)-ad Renoceptor gene expression, protein kinase A, andprotein kinase C in major depression disorder. Expand
G proteins: implications for psychiatry.
  • H. Manji
  • Biology, Medicine
  • The American journal of psychiatry
  • 1992
The author reviews the literature dealing with G protein coupling to second messenger generation, the role of G protein in regulating both the convergence and divergence of neurotransmitter action in the CNS, and the involvement of G proteins in a variety of clinical conditions, with an emphasis on psychiatric conditions and their treatments. Expand