Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium.

@article{Baxter1995InvolvementOP,
  title={Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium.},
  author={Gary F. Baxter and Fastone Matthew Goma and Derek M Yellon},
  journal={British journal of pharmacology},
  year={1995},
  volume={115 2},
  pages={222-4}
}
Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 +/- 4.3% to 31.8 +/- 3.5% (P < 0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed… CONTINUE READING

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