Involvement of protein kinase C in superoxide anion-induced activation of nuclear factor-kappa B in human endothelial cells.

@article{Ogata2000InvolvementOP,
  title={Involvement of protein kinase C in superoxide anion-induced activation of nuclear factor-kappa B in human endothelial cells.},
  author={Nobuhiko Ogata and Hideyuki Yamamoto and Kiyotaka Kugiyama and Hirofumi Yasue and Etsuko Miyamoto},
  journal={Cardiovascular research},
  year={2000},
  volume={45 2},
  pages={
          513-21
        }
}
OBJECTIVE Nuclear factor-kappa B (NF-kappa B) plays an important role in the regulation of redox-sensitive genes which are related to the pathogenesis of various vascular diseases. Although oxygen free-radicals are known to activate NF-kappa B, the signaling pathway of oxygen free radical-induced NF-kappa B activation remains largely unclear. Thus, this study was performed to examine the possible involvement of protein kinase C (PKC) in the oxygen free radical-induced NF-kappa B activation in… CONTINUE READING
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