Involvement of protein kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic beta-cells.

@article{Hy2003InvolvementOP,
  title={Involvement of protein kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic beta-cells.},
  author={Marianne H\oy and P. -O. Berggren and Jesper Gromada},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 37},
  pages={35168-71}
}
Inositolhexakisphosphate (InsP6) plays a pivotal role in the pancreatic beta-cell stimulus-secretion coupling. We have used capacitance measurements to study the effects of InsP6 on Ca2+-dependent exocytosis in single mouse pancreatic beta-cells. In the presence of inhibitors of the protein phosphatase calcineurin to block endocytosis, intracellular application of InsP6 produced a dose-dependent stimulation of exocytosis, and half-maximal effect was observed at 22 microM. The stimulatory effect… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Ionic mechanisms in pancreatic β cell signaling

Cellular and Molecular Life Sciences • 2014

Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron.

Proceedings of the National Academy of Sciences of the United States of America • 2012

Similar Papers

Loading similar papers…